The settings which is making the biggest difference is camber, positive will give you grip but destroy tyres.
Then the wings (more wings gives you grip, slow down the car, which will be less slippery and avoid tyres consumption).
Finally the anti-roll bars, stiffer makes it more accurate but also slippery which makes car acceleration deteriorating tyres easily.
Find a good compromise with all of them and you should find a good setup. This year a lot depends on your driving style, if you are aggresssive won't help at all. Don' expect tyres to last 10 laps more, if you gain 3-4 laps you already found a good compromise.
Hope this will help you.