From what I have read about the Hybrid, the Momentus from Seagate is the only option to consider. It is a 2.5" drive that uses 4gig of flash memory to help speed things up after you have launched an app more than once. This won't show much improvement on programs that you only use once in a while as they won't have anything loaded into the flash memory. In order to achieve the best results too, you will have to make sure that you do a clean install of your OS and apps as for some reason cloning a drive doesn't seem to make it work right.
The price on these drives are about twice the cost of normal drives, and the performance is a lot less than twice as fast as a whole, but for apps that you use all the time several times a day, then those will show a large decrease in the amount of time it takes to launch. For the money, I would consider using a pair of nice fast reliable normal HD's and stripe them in a RAID array
For $80 US, you can get a pair of 7200 RPM 500 gig drives, as compared to the Momentus that costs $100 for a single 500 Gb drive. In the RAID array, the 2 normal drives will perform better over all than the single drive will with the exception of program launches.
The upside to the hybrid is the obvious increase to performance for frequently used apps. The downside is the cost. The upside to the use of 2 drives in a RAID striped array is the overall performance gain regardless of the frequency of use of a program. The downside is that if a single drive fails, you lose all data, not just what was stored on the single drive. If the RAID array is looking good and you want security too, then you can always use 4 drives to set up an array that is striped as well as redundant to give you data peace of mind.