I mainly play AMS and rF2, more on rF2 right now because of GT3's. I tried your set up and it feels good. Without the SC4 software my rotation stays at 900 deg(what I have in settings-wheel-device) no matter what car I use for both games. The in-game auto rotation does not work for me so i let my profiles active while playing. I thought there's some lines I need to change in config files of the game.Sorry if I missed it but, what game are you referring to? Auto-rotation (steering-lock) works differently in some titles; some require file edits to enable while others may work well with an average wheel-rotation setting (540 degrees for example). Others may work by adjusting steering-lock per car while saving your preference.
IIRC, iRacing / AC's soft-lock should work automatically. rF2 may still require custom file edits (not sure if S397 updated the AF preset). AMS works pretty well for me with about 600 degrees set in the wheel-driver.
SC4 can save custom profiles per game / per car / per track / per setup, etc., so it's just a matter of how you want to set things up. Use SC4 to launch the game or you can alt+tab to SC4 and launch the desired profile at any time. You can also define other supporting programs for SC4 to run for you when launching profiles.
edit. Do you have that sudden wheel spin in ACC when you're on the car then escaping to menu? That's why I'm avoiding ACC for now. Not just me but some other AF owners.