Another option which I would try, is very similar to changing ports.(if you are comfortable with it)
Go into the device manager, select your USB hubs/ports, and un-install them. You would then have to re-boot your machine. Windows will re-discover the ports via Plug and Play, re-installing a fresh set of USB drivers.
Sounds drastic, but it isn't really
It just gets awkward if you have a USB mouse, especially if you are unlucky enough to un-install it's port first .....
So if you actually KNOW which USB port (in the device manager) that the wheel is connected to, then you would just un-install that one. It's not always easy to find out if you have lots of USB devices though..
Otherwise you are running out of options ....